Insulin-like growth factors and the multiplication of Tera-2, a human teratoma-derived cell line.

نویسندگان

  • C Biddle
  • C H Li
  • P N Schofield
  • V E Tate
  • B Hopkins
  • W Engstrom
  • N S Huskisson
  • C F Graham
چکیده

A human teratoma cell line (Tera-2) was grown in serum-free medium, and the population multiplication was stimulated by the addition of somatomedins/insulin-like growth factors (IGFs). Both IGF-I and IGF-II gave maximal stimulation when added daily at 10 ng ml-1. The IGFs did not substantially change the labelling index of the cells, and the IGFs appeared to exert their effect on population multiplication by increasing cell survival. Membranes isolated from Tera-2 cells displayed both type 1 and type 2 IGF receptors.

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عنوان ژورنال:
  • Journal of cell science

دوره 90 ( Pt 3)  شماره 

صفحات  -

تاریخ انتشار 1988